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First published online on June 7, 2007.
 Copyright © 2007 by The Physiological Society
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jphysiol.2007.136051v1
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Received May 10, 2007
Revised May 31, 2007
Accepted after revision June 6, 2007

Glucocorticoids and insulin both modulate caloric intake through actions on the brain

Mary F Dallman1*, James P Warne2, Michelle T Foster2, and Norman C Pecoraro2

1 Univ of California at San Francisco
2 UCSF

* To whom correspondence should be addressed. E-mail: mary.dallman{at}ucsf.edu.

Glucocorticoids act primarily in a feed-forward fashion on brain to activate CNS pathways that implement wanting appropriate to physiological needs. Thus, depending on the available conditions, elevated glucocorticoids may augment the behavioral want to run, fight or feed. Although glucocorticoids stimulate intake of chow, fat and sucrose, insulin appears to sculpt calorie-associated desires toward foods high in fat, acting through hepatic branch afferents of the vagus nerve. Both conditions of reduced food allowance and chronic stress excite glucocorticoid-augmented central neural networks that may lead toward ultimate abdominal obesity.


Key words: food intake • glucocorticoids • insulin




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