Ischemia-induced skeletal muscle angiogenesis is impaired in aged compared to young mice. In humans, vascular endothelial growth factor (VEGF) mRNA and protein following an acute exercise bout are lower in aged compared to young untrained men. We hypothesized that exercise-induced skeletal muscle angiogenesis would be attenuated in aged compared to young men. In eight aged (mean age: 64 yrs) and six young (mean age: 25 yrs) sedentary men, vastus lateralis muscle biopsies were obtained from the vastus lateralis prior to (PRE), after 1 week (1WK), and after 8 weeks (8WKS) of an aerobic exercise training program for the measurement of capillarization and VEGF mRNA. Dialysate VEGF protein collected from the muscle interstitial space was measured at rest and during sub-maximal exercise at PRE, 1WK, and 8WKS. Exercise training increased capillary contacts (CC) and capillary-to-fiber perimeter exchange index (CFPE) of type I and IIA fibers similarly in young and aged. The CC of type IIA and IIB fibers was lower in aged compared to young independent of training status. Exercise-induced interstitial VEGF protein was lower in aged compared to young independent of training status. In untrained, greater exercise-induced interstitial VEGF protein during exercise was associated with greater Type I, IIA, and IIB CC. Exercise training increased VEGF mRNA similarly in young and aged. These results demonstrate that the angiogenic response to aerobic exercise training is not altered during the aging process in humans. In addition, muscular activity associated increases in interstitial VEGF protein may play an important role in the maintenance of skeletal muscle capillarization across the life span.