Cholinergic modulation of hippocampal cells and circuits
- 1Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK2Psychiatry CEDD, GlaxoSmithKline Pharmaceuticals Plc, New Frontiers Science Park North, Third Avenue, Harlow, Essex CM19 5AW, UK
- Corresponding author S. R. Cobb: Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Email: s.cobb{at}bio.gla.ac.uk
Abstract
Septo-hippocampal cholinergic fibres ramify extensively throughout the hippocampal formation to release acetylcholine upon a diverse range of muscarinic and nicotinic acetylcholine receptors that are differentially expressed by distinct populations of neurones. The resultant modulation of cellular excitability and synaptic transmission within hippocampal circuits underlies the ability of acetylcholine to influence the dynamic properties of the hippocampal network and results in the emergence of a range of stable oscillatory network states. Recent findings suggest a multitude of actions contribute to the oscillogenic properties of acetylcholine which are principally induced by activation of muscarinic receptors but also regulated through activation of nicotinic receptor subtypes.
Footnotes
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In memory of Eberhard H. Buhl. This report was presented at The Journal of Physiology Symposium in honour of the late Eberhard H. Buhl on Structure/Function Correlates in Neurons and Networks, Leeds, UK, 10 September 2004. It was commissioned by the Editorial Board and reflects the views of the authors.
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- Accepted November 4, 2004.
- Received September 30, 2004.
- Revision received October 27, 2004.
- The Physiological society 2004
