Microarrays and the microscope: balancing throughput with resolution
- Departments of 1Neurology, Program in Neurogenetics2Psychiatry3Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
- Corresponding author D. H. Geschwind: Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Email: dhg{at}mednet.ucla.edu
Abstract
The cellular complexity of the brain is a major issue in the planning, execution and interpretation of microarray studies. Recent technical advances allow for high-throughput study of specific cell populations and circuits. Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis.
Footnotes
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- Accepted June 22, 2006.
- Received May 1, 2006.
- Revision received June 21, 2006.
- 2006 The Authors. Journal compilation © 2006 The Physiological Society
