GABAergic signalling to adult-generated neurons
- 1Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
- Corresponding author L. Overstreet-Wadiche: Neurobiology Department, Shel 1003, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA. Email: lwadiche{at}uab.edu
Abstract
New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step-wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity-dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis.
Footnotes
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(Received 22 April 2008; accepted after revision 28 May 2008; first published online 29 May 2008)
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This report was presented at The Journal of Physiology Symposium on The role of GABA and glutamate on adult neurogenesis, which took place at Experimental Biology 2008, San Diego, CA, USA, 9 April 2008. It was commissioned by the Editorial Board and reflects the views of the authors.
