Voltage-sensing phosphatase: actions and potentials
- 1Department of Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan2Department of Physiology 1, Tohoku University School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan3Department of Molecular and Cellular Biology, Harvard University, Northwest building 348.20, 52 Oxford St, Cambridge, MA 02138, USA
- Corresponding author Y. Okamura: Department of Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. Email: yokamura{at}phys2.med.osaka-u.ac.jp
Abstract
Voltage sensors have been well studied in voltage-gated ion channels for neuronal excitation and muscle contraction. The recent discovery of a voltage-sensing phosphatase, VSP, has changed the idea that voltage sensors are unique to ion flux through membranes. Recent findings on mechanisms and potential applications of VSP are reviewed.
Footnotes
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(Received 10 September 2008; accepted after revision 2 December 2008; first published online 15 December 2008)
