Topical Review:

Johan H. Koeslag, Peter T. Saunders, and Elmarie Terblanche

A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex
J Physiol 2003 549: 333-346. First Published online on April 25, 2003 [Abstract] [Full Text] [PDF]  

Rapid Reports:

Morten Grunnet, Thomas Jespersen, Nanna MacAulay, Nanna K. Jørgensen, Nicole Schmitt, Olaf Pongs, Søren-Peter Olesen, and Dan A. Klaerke

KCNQ1 channels sense small changes in cell volume
J Physiol 2003 549: 419-427. First Published online on April 17, 2003 [Abstract] [Full Text] [PDF]  

Research Papers:

Claudia Altomare, Benedetta Terragni, Chiara Brioschi, Raffaella Milanesi, Cinzia Pagliuca, Carlo Viscomi, Anna Moroni, Mirko Baruscotti, and Dario DiFrancesco

Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node
J Physiol 2003 549: 347-359. First Published online on April 17, 2003 [Abstract] [Full Text] [PDF]  

Trevor M. Lewis, Peter R. Schofield, and Annette M. L. McClellan

Kinetic determinants of agonist action at the recombinant human glycine receptor
J Physiol 2003 549: 361-374. First Published online on April 4, 2003 [Abstract] [Full Text] [PDF]  

Xiandi Gong and Paul Linsdell

Coupled movement of permeant and blocking ions in the CFTR chloride channel pore
J Physiol 2003 549: 375-385. First Published online on April 4, 2003 [Abstract] [Full Text] [PDF]  

Xiandi Gong and Paul Linsdell

Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore
J Physiol 2003 549: 387-397. First Published online on April 4, 2003 [Abstract] [Full Text] [PDF]  

M. Teresa Magalhães-Cardoso, M. Fátima Pereira, Laura Oliveira, J. A. Ribeiro, Rodrigo A. Cunha, and Paulo Correia-de-Sá

Ecto-AMP deaminase blunts the ATP-derived adenosine A_2A receptor facilitation of acetylcholine release at rat motor nerve endings
J Physiol 2003 549: 399-408. First Published online on April 4, 2003 [Abstract] [Full Text] [PDF]  

Maria Hill and Geoffrey Goldspink

Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage
J Physiol 2003 549: 409-418. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

Yukun Yuan, Masahiko Shimura, and Bret A. Hughes

Regulation of inwardly rectifying K⁺ channels in retinal pigment epithelial cells by intracellular pH
J Physiol 2003 549: 429-438. First Published online on March 28, 2003 [Abstract] [Full Text] [PDF]  

Claudia Jatzke, Matthew Hernandez, and Lonnie P. Wollmuth

Extracellular vestibule determinants of Ca²⁺ influx in Ca²⁺-permeable AMPA receptor channels
J Physiol 2003 549: 439-452. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

H. Criss Hartzell and Zhiqiang Qu

Chloride currents in acutely isolated Xenopus retinal pigment epithelial cells
J Physiol 2003 549: 453-469. First Published online on March 28, 2003 [Abstract] [Full Text] [PDF]  

Matthew E. Larkum, Shigeo Watanabe, Takeshi Nakamura, Nechama Lasser-Ross, and William N. Ross

Synaptically activated Ca²⁺ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons
J Physiol 2003 549: 471-488. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

A. Wirth, M. Schroeter, C. Kock-Hauser, E. Manser, J. M. Chalovich, P. de Lanerolle, and G. Pfitzer

Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1
J Physiol 2003 549: 489-500. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

Angus M. Brown, Selva Baltan Tekkök, and Bruce R. Ransom

Glycogen regulation and functional role in mouse white matter
J Physiol 2003 549: 501-512. First Published online on April 4, 2003 [Abstract] [Full Text] [PDF]  

Sabzali A. Javadov, Samantha Clarke, Manika Das, Elinor J. Griffiths, Kelvin H. H. Lim, and Andrew P. Halestrap

Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart
J Physiol 2003 549: 513-524. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF] Supplementary material  

O. Bachmann, K. Wüchner, H. Rossmann, J. Leipziger, B. Osikowska, W. H. Colledge, R. Ratcliff, M. J. Evans, M. Gregor, and U. Seidler

Expression and regulation of the Na⁺-K⁺-2Cl^- cotransporter NKCC1 in the normal and CFTR-deficient murine colon
J Physiol 2003 549: 525-536. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

Andrea Burgo, Giorgio Carmignoto, Paola Pizzo, Tullio Pozzan, and Cristina Fasolato

Paradoxical Ca²⁺ rises induced by low external Ca²⁺ in rat hippocampal neurones
J Physiol 2003 549: 537-552. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

Jun Yamanaka, Junji Nishimura, Katsuya Hirano, and Hideo Kanaide

An important role for the Na⁺-Ca²⁺ exchanger in the decrease in cytosolic Ca²⁺ concentration induced by isoprenaline in the porcine coronary artery
J Physiol 2003 549: 553-562. First Published online on May 9, 2003 [Abstract] [Full Text] [PDF]  

Ruben Guzmán-Marín, Natalia Suntsova, Darya R. Stewart, Hui Gong, Ronald Szymusiak, and Dennis McGinty

Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats
J Physiol 2003 549: 563-571. First Published online on April 4, 2003 [Abstract] [Full Text] [PDF]  

Charles E. Wood and Damian Giroux

Central nervous system prostaglandin endoperoxide synthase-1 and -2 responses to oestradiol and cerebral hypoperfusion in late-gestation fetal sheep
J Physiol 2003 549: 573-581. First Published online on April 17, 2003 [Abstract] [Full Text] [PDF]  

Sophie L. Pearce, Timothy S. Miles, Philip D. Thompson, and Michael A. Nordstrom

Responses of single motor units in human masseter to transcranial magnetic stimulation of either hemisphere
J Physiol 2003 549: 583-596. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

Brad J. Behnke, Paul McDonough, Danielle J. Padilla, Timothy I. Musch, and David C. Poole

Oxygen exchange profile in rat muscles of contrasting fibre types
J Physiol 2003 549: 597-605. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

Mark A. Febbraio, Adam Steensberg, Charlotte Keller, Rebecca L. Starkie, Henning B. Nielsen, Peter Krustrup, Peter Ott, Niels H. Secher, and Bente K. Pedersen

Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans
J Physiol 2003 549: 607-612. First Published online on April 17, 2003 [Abstract] [Full Text] [PDF]  

Andrew M. Coney and Janice M. Marshall

Contribution of adenosine to the depression of sympathetically evoked vasoconstriction induced by systemic hypoxia in the rat
J Physiol 2003 549: 613-623. First Published online on April 17, 2003 [Abstract] [Full Text] [PDF] Supplementary material  

Christian J. Hunter, Arlin B. Blood, Charles R. White, William J. Pearce, and Gordon G. Power

Role of nitric oxide in hypoxic cerebral vasodilatation in the ovine fetus
J Physiol 2003 549: 625-633. First Published online on March 28, 2003 [Abstract] [Full Text] [PDF]  

Martial Dangin, Christelle Guillet, Clara Garcia-Rodenas, Pierre Gachon, Corinne Bouteloup-Demange, Kristel Reiffers-Magnani, Jacques Fauquant, Olivier Ballèvre, and Bernard Beaufrère

The rate of protein digestion affects protein gain differently during aging in humans
J Physiol 2003 549: 635-644. First Published online on March 28, 2003 [Abstract] [Full Text] [PDF] Supplementary material  

M. Khassaf, A. McArdle, C. Esanu, A. Vasilaki, F. McArdle, R. D. Griffiths, D. A. Brodie, and M. J. Jackson

Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle
J Physiol 2003 549: 645-652. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

T. Cartmell, C. Ball, A. F. Bristow, D. Mitchell, and S. Poole

Endogenous interleukin-10 is required for the defervescence of fever evoked by local lipopolysaccharide-induced and Staphylococcus aureus-induced inflammation in rats
J Physiol 2003 549: 653-664. First Published online on April 11, 2003 [Abstract] [Full Text] [PDF]  

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