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The cover illustration shows Ca²⁺ imaging with every beat of the heart. At the left the two states of the genetically encoded Ca²⁺ indicator, GCaMP2, are shown. Ca²⁺ ions (red balls) bind to the C−terminal calmodulin, producing an interaction between the -N and -C termini of the fusion protein, and fluorescence. At the right a transgenic mouse expressing the Ca²⁺ sensor protein with a superimposed in vivo image of the heart captured at peak contraction and fluorescence. The sensor allows stable, real−time measurements of Ca²⁺ in vivo and surface excitation mapping. Recent advances in genetically encoded Ca²⁺ sensors are described in Kotlikoff, pp.55–67. Photograph and drawings courtesy of Alexis Wenski−Roberts and Michael A. Simmons, MFA