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The cover illustration shows electrical potential distributions within the Na channel pore resulting from binding of positively charged lidocaine to Phe-1759 below the selectivity filter or mutation of Phe-1759 to charged residues. Top row: on-face view of proposed lidocaine binding in the pore and electrical potential distributions in WT. Middle row: studies of electrical potentials with mutant F1759K and differences from lidocaine. Bottom row: studies with F1759E and F1759D. See McNulty et al. pp. 741-755.