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The cover image shows left, illustration of alternative pathways leading to the release of mobile polyunsaturated fatty acids from the lipid bilayer into the cytosol; see Darios et al. pp. 699-704.Upper right, illustration of multiple synaptic vesicle retrieval pathways in central nerve terminals; see Clayton et al. pp. 687-691. Lower right, illustration of TOM-1 negatively regulating UNC-13-dependent synaptic vesicle priming; see Gracheva et al. pp. 705-709. Lower panel, illustration of the action of polyunsaturated fatty acids on syntaxin; see Darios et al. pp. 699-704.