PERSPECTIVES:

Stephen G. Waxman and Mark Estacion

Na_v1.9, G-proteins, and nociceptors
J Physiol 2008 586: 917-918
DOI: 10.1113/jphysiol.2007.149922 [Full Text] [PDF]  

Jutta Engel

Gerbils can tune in
J Physiol 2008 586: 919
DOI: 10.1113/jphysiol.2007.150409 [Full Text] [PDF]  

Matthew C. Walker

GABA_A receptor subunit specificity: a tonic for the excited brain
J Physiol 2008 586: 921-922
DOI: 10.1113/jphysiol.2007.150581 [Full Text] [PDF]  

Reese S. Scroggs

Evidence of a physiological role for use-dependent inactivation of Na_V1.8 sodium channels
J Physiol 2008 586: 923
DOI: 10.1113/jphysiol.2008.150821 [Full Text] [PDF]  

JOURNAL CLUB:

Xinjiang Cai

Subunit stoichiometry and channel pore structure of ion channels: all for one, or one for one?
J Physiol 2008 586: 925-926 First Published online on December 13, 2007
DOI: 10.1113/jphysiol.2007.149153 [Full Text] [PDF]  

Sandeep S. Hothi and Matthew J. Killeen

The role of I_Ks in atrial arrhythmogenesis
J Physiol 2008 586: 927-928 First Published online on December 20, 2007
DOI: 10.1113/jphysiol.2007.149534 [Full Text] [PDF]  

TOPICAL REVIEW:

Glenna C. L. Bett and Randall L. Rasmusson

Modification of K⁺ channel–drug interactions by ancillary subunits
J Physiol 2008 586: 929-950 First Published online on December 20, 2007
DOI: 10.1113/jphysiol.2007.139279 [Abstract] [Full Text] [PDF]  

MOLECULAR AND GENOMIC:

Deeptankar Demazumder and James P. Dilger

The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature
J Physiol 2008 586: 951-963 First Published online on December 6, 2007
DOI: 10.1113/jphysiol.2007.143289 [Abstract] [Full Text] [PDF]  

NEUROSCIENCE:

Dianne R. Peden, Caroline M. Petitjean, Murray B. Herd, Murat S. Durakoglugil, Thomas W. Rosahl, Keith Wafford, Gregg E. Homanics, Delia Belelli, Jean-Marc Fritschy, and Jeremy J. Lambert

Developmental maturation of synaptic and extrasynaptic GABA_A receptors in mouse thalamic ventrobasal neurones
J Physiol 2008 586: 965-987 First Published online on December 6, 2007
DOI: 10.1113/jphysiol.2007.145375 [Abstract] [Full Text] [PDF]  

Murray B. Herd, Alison R. Haythornthwaite, Thomas W. Rosahl, Keith A. Wafford, Gregg E. Homanics, Jeremy J. Lambert, and Delia Belelli

The expression of GABA_A β subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells
J Physiol 2008 586: 989-1004 First Published online on December 13, 2007
DOI: 10.1113/jphysiol.2007.146746 [Abstract] [Full Text] [PDF]  

Ava Chomee Yoon, Vinnie Kathpalia, Sahana D'Silva, Aylin Cimenser, and Shao-Ying Hua

Determining Ca²⁺-sensor binding time and its variability in evoked neurotransmitter release
J Physiol 2008 586: 1005-1015 First Published online on December 6, 2007
DOI: 10.1113/jphysiol.2007.130740 [Abstract] [Full Text] [PDF]  

Yann Duclos, Annie Schmied, Boris Burle, Henri Burnet, and Christiane Rossi-Durand

Anticipatory changes in human motoneuron discharge patterns during motor preparation
J Physiol 2008 586: 1017-1028 First Published online on December 13, 2007
DOI: 10.1113/jphysiol.2007.145318 [Abstract] [Full Text] [PDF]  

Matthew Edward Pamenter, Damian Seung-Ho Shin, Mohan Cooray, and Leslie Thomas Buck

Mitochondrial ATP-sensitive K⁺ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle
J Physiol 2008 586: 1043-1058 First Published online on December 13, 2007
DOI: 10.1113/jphysiol.2007.142380 [Abstract] [Full Text] [PDF]  

Alain Delpy, Anne-Emilie Allain, Pierre Meyrand, and Pascal Branchereau

NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron
J Physiol 2008 586: 1059-1075 First Published online on December 20, 2007
DOI: 10.1113/jphysiol.2007.146993 [Abstract] [Full Text] [PDF]  

Roberto De Col, Karl Messlinger, and Richard W. Carr

Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges
J Physiol 2008 586: 1089-1103 First Published online on December 20, 2007
DOI: 10.1113/jphysiol.2007.145383 [Abstract] [Full Text] [PDF]  

Elaine A. Gay, Rashid Giniatullin, Andrei Skorinkin, and Jerrel L. Yakel

Aromatic residues at position 55 of rat 7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization
J Physiol 2008 586: 1105-1115 First Published online on December 20, 2007
DOI: 10.1113/jphysiol.2007.149492 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

M. Kooijman, D. H. J. Thijssen, P. C. E. de Groot, M. W. P. Bleeker, H. J. M. van Kuppevelt, D. J. Green, G. A. Rongen, P. Smits, and M. T. E. Hopman

Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans
J Physiol 2008 586: 1137-1145 First Published online on December 20, 2007
DOI: 10.1113/jphysiol.2007.145722 [Abstract] [Full Text] [PDF]  

Pamela D. Smith, Suzanne E. Brett, Kevin D. Luykenaar, Shaun L. Sandow, Sean P. Marrelli, Edward J. Vigmond, and Donald G. Welsh

K_IR channels function as electrical amplifiers in rat vascular smooth muscle
J Physiol 2008 586: 1147-1160 First Published online on December 6, 2007
DOI: 10.1113/jphysiol.2007.145474 [Abstract] [Full Text] [PDF]  

Michael D. Delp, Bradley J. Behnke, Scott A. Spier, Guoyao Wu, and Judy M. Muller-Delp

Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles
J Physiol 2008 586: 1161-1168 First Published online on December 6, 2007
DOI: 10.1113/jphysiol.2007.147686 [Abstract] [Full Text] [PDF]  

ALIMENTARY:

Sung Jin Hwang, Neil O'Kane, Cherie Singer, Sean M. Ward, Kenton M. Sanders, and Sang Don Koh

Block of inhibitory junction potentials and TREK-1 channels in murine colon by Ca²⁺ store-active drugs
J Physiol 2008 586: 1169-1184 First Published online on January 10, 2008
DOI: 10.1113/jphysiol.2007.148718 [Abstract] [Full Text] [PDF]  

RENAL AND ENDOCRINE:

Eva Szarek, Kirsten Farrand, I. Caroline McMillen, I. Ross Young, Daniel Houghton, and Jeffrey Schwartz

Hypothalamic input is required for development of normal numbers of thyrotrophs and gonadotrophs, but not other anterior pituitary cells in late gestation sheep
J Physiol 2008 586: 1185-1194 First Published online on December 20, 2007
DOI: 10.1113/jphysiol.2007.141523 [Abstract] [Full Text] [PDF]  

INTEGRATIVE:

Brad W. Wilkins, Tasha L. Pike, Elizabeth A. Martin, Timothy B. Curry, Maile L. Ceridon, and Michael J. Joyner

Exercise intensity-dependent contribution of β-adrenergic receptor-mediated vasodilatation in hypoxic humans
J Physiol 2008 586: 1195-1205 First Published online on November 29, 2007
DOI: 10.1113/jphysiol.2007.144113 [Abstract] [Full Text] [PDF]  

LETTERS:

Nicolas Place

Is interstitial K⁺ accumulation a key factor in the fatigue process under physiological conditions?
J Physiol 2008 586: 1207-1208 First Published online on January 10, 2008
DOI: 10.1113/jphysiol.2007.150292 [Full Text] [PDF]  

Torben Clausen and Ole Bækgaard Nielsen

Reply from Torben Clausen and Ole Bækgaard Nielsen
J Physiol 2008 586: 1209 First Published online on January 10, 2008
DOI: 10.1113/jphysiol.2007.150300 [Full Text] [PDF]  

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