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The cover image shows, top left, ribbon structure diagram of the KCNQ1 structure in the N-terminal juxtamembranous domain, from Peroz et al. pp.1785–1789 ; top middle, structure of Kv7 channels, from Haitin & Attali, pp.1803–1810 ; top right, structural model exploring the role of the S1�S2 region in voltage-dependent gating of the KV7.2 channel, from Maljevic et al. pp.1791–1801 ; middle left, M channel regulation in sympathetic neurons, from Hernandez et al. pp. 1811–1821 ; middle middle, a G_q/11-coupled receptor, from Hernandez et al.; middle right, a schematic depiction of movement of the PLCδ-PH probe after activation of PLC via stimulation G_q/11-coupled receptors, from Hernandez et al.; bottom left and bottom right, hippocampal neurons obtained from E18 mouse embryos stained with antibodies directed against MAP-2, a somato-dendritic marker, KV7.3, and DAPI (nucleus), from Maljevic et al.; bottom middle, schematic view of KV7 and KV7 subunit depicting mutations, from Maljevic et al.