PERSPECTIVES:

Claudia Eder

A mysterious channel: new insights into proton channel functioning raise new questions
J Physiol 2008 586: 2419-2420
DOI: 10.1113/jphysiol.2008.154625 [Full Text] [PDF]  

Allan Vaag

To be predisposed to insulin resistance and type 2 diabetes
J Physiol 2008 586: 2421
DOI: 10.1113/jphysiol.2008.154856 [Full Text] [PDF]  

JOURNAL CLUB:

Viviana Muñoz, Katherine Campbell, and Junko Shibayama

Fibroblasts: modulating the rhythm of the heart
J Physiol 2008 586: 2423-2424 First Published online on March 20, 2008
DOI: 10.1113/jphysiol.2008.153387 [Full Text] [PDF]  

Armin Akhavan

Contribution of pacemaker channels to autonomous electrical activity of differentiated embryonic stem cells
J Physiol 2008 586: 2425-2426 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2008.153338 [Full Text] [PDF]  

Daniele Orsucci, Michelangelo Mancuso, and Gabriele Siciliano

Mitochondria, oxidative stress and PARP-1 network: a new target for neuroprotective effects of tetracyclines?
J Physiol 2008 586: 2427-2428 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2008.152819 [Full Text] [PDF]  

TOPICAL REVIEW:

Nicholas Dale

Dynamic ATP signalling and neural development
J Physiol 2008 586: 2429-2436 First Published online on March 20, 2008
DOI: 10.1113/jphysiol.2008.152207 [Abstract] [Full Text] [PDF]  

TECHNIQUES FOR PHYSIOLOGY:

W. Gil Wier, Mark A. Rizzo, Hema Raina, and Joseph Zacharia

A technique for simultaneous measurement of Ca²⁺, FRET fluorescence and force in intact mouse small arteries
J Physiol 2008 586: 2437-2443 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2008.151522 [Abstract] [Full Text] [PDF]  

MOLECULAR AND GENOMIC:

Seunghoon Oh, Vytas K. Verselis, and Thaddeus A. Bargiello

Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannel
J Physiol 2008 586: 2445-2461 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2008.150805 [Abstract] [Full Text] [PDF]  

CELLULAR:

B. Musset, V. V. Cherny, D. Morgan, Y. Okamura, I. S. Ramsey, D. E. Clapham, and T. E. DeCoursey

Detailed comparison of expressed and native voltage-gated proton channel currents
J Physiol 2008 586: 2477-2486 First Published online on March 20, 2008
DOI: 10.1113/jphysiol.2007.149427 [Abstract] [Full Text] [PDF]  

NEUROSCIENCE:

Ian T. Gordon and Patrick J. Whelan

Brainstem modulation of locomotion in the neonatal mouse spinal cord
J Physiol 2008 586: 2487-2497 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2007.148320 [Abstract] [Full Text] [PDF] Supplemental Data  

Peter R. Moult, Sônia A. L. Corrêa, Graham L. Collingridge, Stephen M. Fitzjohn, and Zafar I. Bashir

Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression
J Physiol 2008 586: 2499-2510 First Published online on March 20, 2008
DOI: 10.1113/jphysiol.2008.153122 [Abstract] [Full Text] [PDF]  

Terumasa Nakatsuka, Tsugumi Fujita, Kazuhide Inoue, and Eiichi Kumamoto

Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin
J Physiol 2008 586: 2511-2522 First Published online on March 20, 2008
DOI: 10.1113/jphysiol.2007.146076 [Abstract] [Full Text] [PDF]  

Karina Alviña and Kamran Khodakhah

Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats
J Physiol 2008 586: 2523-2538 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2007.148197 [Abstract] [Full Text] [PDF] Supplemental Data  

Hideki Miwa, Masahiro Fukaya, Ayako M. Watabe, Masahiko Watanabe, and Toshiya Manabe

Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS
J Physiol 2008 586: 2539-2550 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2007.147652 [Abstract] [Full Text] [PDF]  

Deb Kumar Mojumder, David M. Sherry, and Laura J. Frishman

Contribution of voltage-gated sodium channels to the b-wave of the mammalian flash electroretinogram
J Physiol 2008 586: 2551-2580 First Published online on April 3, 2008
DOI: 10.1113/jphysiol.2008.150755 [Abstract] [Full Text] [PDF] Supplemental Data  

CARDIOVASCULAR:

Zhaohui Gao, Satoshi Koba, Lawrence Sinoway, and Jianhua Li

20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents
J Physiol 2008 586: 2581-2591 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2008.150730 [Abstract] [Full Text] [PDF]  

SKELETAL MUSCLE AND EXERCISE:

Pilar Negredo, José-Luis L. Rivero, Beatriz González, Almudena Ramón-Cueto, and Rafael Manso

Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation
J Physiol 2008 586: 2593-2610 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2007.149120 [Abstract] [Full Text] [PDF]  

INTEGRATIVE:

Kazuhiro Nakamura and Shaun F. Morrison

Preoptic mechanism for cold-defensive responses to skin cooling
J Physiol 2008 586: 2611-2620 First Published online on April 3, 2008
DOI: 10.1113/jphysiol.2008.152686 [Abstract] [Full Text] [PDF]  

Stefan P. Mortensen, Rasmus Damsgaard, Ellen A. Dawson, Niels H. Secher, and José González-Alonso

Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and V_O2 during high-intensity whole-body exercise in humans
J Physiol 2008 586: 2621-2635 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2007.149401 [Abstract] [Full Text] [PDF]  

Alison K. Stubbings, Alastair J. Moore, Michael Dusmet, Peter Goldstraw, Timothy G. West, Michael I. Polkey, and Michael A. Ferenczi

Physiological properties of human diaphragm muscle fibres and the effect of chronic obstructive pulmonary disease
J Physiol 2008 586: 2637-2650 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2007.149799 [Abstract] [Full Text] [PDF]  

Mei J. Zhu, Bin Han, Junfeng Tong, Changwei Ma, Jessica M. Kimzey, Keith R. Underwood, Yao Xiao, Bret W. Hess, Stephen P. Ford, Peter W. Nathanielsz, and Min Du

AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep
J Physiol 2008 586: 2651-2664 First Published online on March 27, 2008
DOI: 10.1113/jphysiol.2007.149633 [Abstract] [Full Text] [PDF]  

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